Mimar

The antimicrobial drug Zimar is a fluoroquinolone drug. The active ingredient is gatifloxacin.

Indicações Mimar

Zimar is used to treat the treatment of bacterial conjunctivitis caused by susceptible microbes.

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Forma de liberação

Zimar is a solution that is available in the form of eye drops, 0.3% 5 ml.

It has the appearance of a transparent liquid with a slight yellowish or greenish tint.

Farmacodinâmica

Zimar is active against various gram-negative and gram-positive microorganisms. Antimicrobial effect of the drug is to inhibit the enzymes of pathogenic microorganisms. DNA gyrase is a complex enzyme that participates in the processes of replication, transcription and recovery of microbial DNA.

Zimar is active in relation to staphylococcus, streptococcus, escherichia, Klebsiella, hemophilus bacillus, moraccella, neysheria, Proteus, chlamydia, legionella, mycoplasma, peptostreptokokkam.

Farmacocinética

Internal and injectable use Gatispan is interchangeable: the kinetic parameters after injection for 60 minutes are similar in parameters with the internal administration of the drug.

The connection with plasma proteins can be about 20%: there is no dependence on the content of the drug in the blood.

Due to the relatively small association with plasma proteins, the Gatispan concentration in the salivary fluid is approximately equal to the concentration in the serum. In a state of equilibrium, the average distribution volume of Gatispan can be 1.5-2 liters per kilogram.

Biological transformation of the drug is limited. With urinary fluid, less than 1% of the intake amount of Gatispan (as the products of ethylenediamine and methylethylenediamine) is released.

Gatispan is excreted mainly through the kidneys in an unchanged state (greater than 70% within 48 hours after intravenous injection), and only 5% is excreted with feces.

There are no data on the change in kinetic properties in the treatment of patients with severe hepatic insufficiency.

The kinetic properties of Gatispan when used in children under 18 years of age have not been studied.

Dosagem e administração

Locally. The drug is instilled during waking hours.

On the 1st and 2nd day, instill 1 drop into the affected eye every 2 hours, up to 8 times a day. From the 3rd to the 7th day, instill 1 drop up to 4 times a day.

Uso Mimar durante a gravidez

Zimar is forbidden to use during pregnancy.

Contra-indicações

Contraindications to treatment with Zimar are:

• hypersensitivity to drugs of the quinolone group;
• children under 18 years of age;
• the entire period of bearing a child and breastfeeding.

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Efeitos colaterais Mimar

 The following clinical manifestations were found during Zimar treatment:

• allergy in the form of edema, vesicular, bullous or papular rash;
• dyspepsia, bloating in the stomach, gastritis, mucosal ulcers, gastric bleeding;
• headache, dizziness, anxiety, irritability, sleep disturbances, trembling and numbness in the extremities, convulsions, panic conditions, changes in taste, hyperesthesia, photophobia;
• increased or slowed heart rate, increased blood pressure, cyanosis;
• shortness of breath, pharyngitis;
• urination disorders, the appearance of blood in the urine;
• bone and joint pain, dry mouth, fever, dry skin and mucous membranes, metrorrhagia, hypoglycemia.

Overdose

Symptoms of overdose Zimar is to slow breathing, nausea, tremors and cramps in the limbs.

Interações com outras drogas

Gatispan does not affect the systemic clearance values after intravenous injection of midazolam. A single intravenous injection of midazolam in an amount of 0.0145 mg per kg does not change the kinetic properties of Gatispan.

The combination of Gatispan and Theophylline did not have a mutual effect on each other.

The combination of Gatispan and Gliburid (1 time per day) in patients with type 2 diabetes did not affect the pharmacological parameters of the drugs: the sugar content in the blood did not change.

No interaction was found between Gatispan and Digoxin, but an increase in the level of Digoxin was noted in 3-11% of patients. Based on this, we can assume the development of intoxication Digoxin.

Excretion of Gatispan from the bloodstream is enhanced when combined with Probenecid.

In patients who were treated with warfarin, simultaneous administration of Gatispan did not cause significant changes in blood clotting. However, in such a situation, there is a need to control the prothrombin index.

It was found that the combination of non-steroidal anti-inflammatory drugs and quinolones can lead to the development of seizures and disorders from the central nervous system.

The combination of Gatispan with tricyclic antidepressants, phenothiazine preparations, as well as with erythromycin and cisapride adds the risk of arrhythmia.

Condições de armazenamento

Zimar kept in a dark place. The temperature in the room should not exceed + 30 ° C. Freeze the drug is prohibited.

Do not allow children to storage places of drugs.

Validade

Zimar is allowed to be stored for two years.