Lamicon

Lamicon is an antimycotic with a wide range of effects.

Indicações Lamicon

Indications for the use of Lamicon are skin candidiasis, head skin fungi, onychomycosis, limb trichophytosis, and also trunk.

[1], [2]

Forma de liberação

Lamicon is available in the form of tablets taken orally, as well as sprays or ointments used externally.

[3]

Farmacodinâmica

The lamino affects the sterol biosynthesis in fungal cells, and also suppresses the activity of the squalene epoxidase enzyme in the plasmalemma, thereby contributing to the death of pathogenic cells. The medicine destroys the fungi of the genus Candida and the organisms that provoke the development of dermatomycosis, and in addition to this, pityriasis.

Lamicon has fungicidal and fungistatic properties that affect yeast fungi. Fungicidal action destroys dimorphic and mold fungi, as well as dermatophytes. The drug has the greatest effect in the destruction of mycelial and mold Candida fungi, as well as the trichophyton of red.

[4], [5], [6], [7]

Farmacocinética

Lamicon is absorbed in the digestive tract, reaching a peak concentration in the blood 2 hours after the use of the tablet. Semi-absorption of the substance occurs after 0.8 hours, and the half-distribution period is 4.6 hours. Binding to plasma proteins - 100%.

There is a selective accumulation of the drug in the skin, as well as its appendages. After 24 hours after a single application of 0.25 g of the agent, the concentration of the active ingredient in the stratum corneum of the epidermis increases by a factor of 10, and after 12 days this factor increases 70-fold. The rate of distribution of the drug exceeds the rate at which nails grow.

Biotransformation occurs in the liver, inactive non-active decay products are formed in the process. Removal of the medicine occurs through the kidneys (about 70%).

[8], [9], [10],

Dosagem e administração

For adults, as well as children weighing more than 40 kg, the dosage is 1 tablet medication after eating (1 time per day). For children weighing less than 40 kg, the dosage is 0.5 tablets.

To treat onychomycosis, a treatment course of 1.5-3 months is prescribed. With fungi of the scalp, soles of the feet, and in addition to these brushes or trunk, as well as cutaneous candidiasis, this course is 0.5-1.5 months.

Ointment Lamikon is applied to adults, and also to children 12+ years 1-2 times per day. Before the procedure, it is necessary to thoroughly wash and dry the skin. The medicine needs to process the affected areas. The duration of the treatment course will depend on the severity of the inflammation, as well as its nature.

The spray is applied externally. Before application, the skin needs to be completely cleaned and well moistened. After this, it is necessary to spray the drug in such a way that the substance is sufficient to moisten the inflamed areas.

The course of treatment is required to be completed, since a premature end of treatment does not exclude a relapse.

[16], [17]

Uso Lamicon durante a gravidez

The medicine is forbidden to use during pregnancy, as well as lactation.

Contra-indicações

Among the contraindications: individual intolerance of the active substance, renal or hepatic pathology in acute or chronic form (there are signs of renal or liver failure), and besides this, oncological pathologies, metabolic disorders, blood diseases. In addition, the drug is prohibited for children under 3 years old.

[11], [12], [13]

Efeitos colaterais Lamicon

Among the side effects of Lamicon, aching pain or a feeling of heaviness in the epigastrium.

Also, there may be dyspeptic manifestations - appetite impairment, taste receptor disorders, diarrhea, nausea, allergies (urticaria), bile duct failure.

In the areas of application of the spray / ointment, redness, itching or burning can occur.

[14], [15]

Overdose

As a result of a drug overdose, headaches and dizziness may occur, and besides this, vomiting with nausea and pain in the epigastrium.

In case of occurrence of similar symptoms it is necessary to wash out a stomach, and also to accept a tablet of the activated coal or other adsorbents. Then carry out symptomatic treatment.

[18]

Interações com outras drogas

When the drug is combined with β-adrenoblockers, the process of biotransformation of terbinafine is suppressed, and the index of its concentration in the blood plasma is also increased.

Due to the combined use of Lamicon with inhibitors of hemoprotein P450, the values of the terbinafine purification coefficient decrease. This indicator is increased when the drug is combined with rifampicin.

[19], [20], [21]

Condições de armazenamento

Contain the Lamicon in a place that is closed from sunlight and moisture under temperature conditions no more than 25 degrees.

Validade

Lamicon is allowed to be used for 3 years from the date of manufacture of the medicine.