Neurotrofina

Neurotropin is a medicinal substance that affects the functioning of the nervous system. The drug has effective antihypoxic activity, protects cell walls together with blood vessels, and also weakens the effect of free radicals on metabolic processes occurring inside the body.

In addition, the drug has a nootropic effect, eliminates attacks of fear and anxiety, reduces the likelihood of seizures, and also protects the nervous system from various external stresses.

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Indicações Neurotropina

It is used for the following disorders:

• cerebral blood flow disorders, which have an acute or chronic degree of development;
• DCE or NCD;
• mild cognitive disorders that appear as a result of the development of atherosclerotic processes;
• anxiety states that develop as a result of neurosis-like disorders and neuroses;
• alcohol withdrawal;
• acute poisoning with neuroleptic substances;
• acute purulent-inflammatory lesions of the peritoneum ( peritonitis or pancreatic necrosis).

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Forma de liberação

The pharmaceutical element is released in the form of an injection liquid - an ampoule with a volume of 2 ml; inside the cell plate - 5 ampoules. In a box - 2 such plates.

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Farmacodinâmica

The principle of the drug's effect is based on the action of the active element on neural conductivity; it significantly increases the body's resistance to damaging factors. The drug increases resistance to hypoxia, shock, cerebral blood flow disorders, ischemia, alcohol poisoning, and the negative effects of antipsychotics (neuroleptics).

Neurotropin helps improve tissue metabolism inside the brain, blood properties, and circulation inside the CNS vascular bed. The positive effect on blood occurs due to the normalization of the action of platelet walls with erythrocytes, as well as the weakening of platelet aggregation.

The drug reduces the amount of lipids in the blood, as well as the values of LDL, VLDL and cholesterol. This effect of the drug is extremely important for people with atherosclerosis.

At the same time, Neurotropin helps to reduce enzymatic toxemia, as well as intraorgan poisoning, which occurs during the development of pancreatitis in the acute stage.

The therapeutic effect of the drug develops due to its membrane-protective and antioxidant activity. The active component of the drug reduces oxidative lipid processes, increases the activity of superoxide oxidase and the "protein/lipid" ratio, and also reduces the viscosity of cell walls.

The drug activates the activity of membrane enzymes (calcium-independent PDE, AC and AChE) and endings (GABA, acetylcholine and benzodiazepine). Due to this, the synthesis of endings with ligands occurs, as well as the improvement of the functions and structure of cell walls, and along with their organization and movement of NS mediators, as well as neuromuscular synapses through these endings.

At the same time, the drug increases dopamine levels in the brain, activates the energy activity of neurocellular mitochondria and helps improve glycolysis with the help of oxygen.

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Farmacocinética

The drug must be administered intramuscularly. After such administration, the active component of the drug is noted in the blood plasma for a 4-hour period. The Cmax values of the drug are recorded after 25-30 minutes and are equal to 3.5-5 mcg/ml with an administered dose of 0.4-0.5 g.

The high rate of intrahepatic and intrarenal metabolism leads to the excretion of the drug in an unchanged or glucuronide-conjugated state.

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Dosagem e administração

The medicine can be administered intravenously (by jet or through a drip) or intramuscularly. The dose size is selected by a health care professional taking into account the patient's personal characteristics, his pathology and the degree of its severity. Neurotropin begins to act approximately 1 hour after administration.

When using the medication intravenously, it is first dissolved in isotonic NaCl (0.2 l). When administered through a dropper, the rate is 40-60 drops per minute, and when administered by jet, the portion must be administered over 5-7 minutes.

For children, therapy should begin with a dose of 0.05-0.1 g 1-3 times a day. Then the dosage volume is gradually increased until the desired result is achieved. The maximum permissible daily dose is 0.8 g.

In case of strokes, the substance is used in a combined regimen - during the first 2-4 days, 0.2-0.3 g of the drug is used once a day (intravenously through a drip or jet), and then administered intramuscularly - 3 times a day in a dose of 0.1 g. The therapeutic course in case of such disorders lasts 10-14 days.

In severe stages of DCE (decompensation stage), the medication is administered intravenously (jet or dropper) - 0.1 g 2-3 times a day for 14 days. Then Neurotropin is used intramuscularly - 0.1 g for another 14 days. To prevent the development of DCE, the substance is used intramuscularly - 0.1-0.3 g per day for 14-30 days.

In case of alcohol withdrawal, the drug is used intramuscularly in a dose of 0.1-0.2 g, 2-3 times a day or through a drip intravenously - 1-2 times a day, for a period of 5-7 days.

In case of acute intoxication with neuroleptics, it is necessary to use the medication in a dosage of 50-300 mg (intravenous administration), 1 time per day for 7-14 days.

In case of acute purulent-inflammatory lesions in the peritoneum (peritonitis, pancreatic necrosis, etc.), the medication is prescribed the day before and the day after the operation. The portion size is determined by the patient's condition, his personal characteristics, the properties of the pathology, and also the degree of its severity. In these cases, the use of the drug should be discontinued only after clinical recovery, as well as positive laboratory results.

In cases of peritoneal lesions (in addition to standard therapy), pulse therapy with Neurotropin can also be used. In this case, 0.8 g of the substance should be administered per day in 2 doses, and then 0.3 g 2 times per day, gradually reducing the portion size.

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Uso Neurotropina durante a gravidez

Testing was not performed regarding the effects of the drug on the body of nursing mothers or pregnant women. In this regard, in these periods, neurotropin is not used.

Contra-indicações

It is contraindicated to administer the drug in case of severe sensitivity to its components, as well as in case of renal or hepatic dysfunction.

The drug should be used with extreme caution in cases of bronchial asthma or a history of severe allergies, because in this case, pronounced immunological signs may occur. In addition, the drug should be administered with caution to people with diabetic retinopathy - due to the risk of proliferative symptoms. In such cases, the treatment cycle should last a maximum of 7-10 days.

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Efeitos colaterais Neurotropina

Among the adverse events:

• disorders of digestive activity: dryness that affects the mucous membranes, diarrhea, nausea, metallic taste, flatulence and severe gas formation;
• disturbances in the work of the central nervous system: problems with falling asleep and sleeping, variability of emotions and moods, movement coordination disorders, anxiety states and headaches;
• lesions affecting the cardiovascular system: a decrease or increase in blood pressure indicators;
• immune manifestations: itching, epidermal swelling, rashes, hyperhidrosis, angioedema, urticaria, and bronchial spasm.

With too high a rate of drug administration in / in the way, a feeling of heat throughout the body, sore throat, tremor, bad smell, tachycardia, dyspnea and facial flushing may appear. Prolonged therapy may lead to the development of peripheral edemas.

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Overdose

Signs of poisoning include sleep disorders and increased blood pressure.

In such cases, symptomatic and detoxifying procedures must be carried out.

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Interações com outras drogas

Neurotropin potentiates the effect of benzodiazepine anxiolytics, antiparkinsonian drugs (levodopa) and anticonvulsants (carbamazepine).

The drug weakens the toxic activity of ethanol.

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Condições de armazenamento

Neurotrophin is required to be kept in a place that is closed to children. Temperature indicators - up to the mark of 25 ° С.

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Validade

Neurotrophin can be used for a 36-month period from the time the medication is sold.

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Application for children

The medication cannot be used in pediatrics (under 18 years of age).

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Analogues

The analogs of the drug are Antifront, Keltikan, Tryptophan with Armadin, Glycised and Huato Boluses with Mexidol, as well as Glycine with Intellan, Rilutek and Glutamic acid. Also on the list are Instenon, Mexiprim, Tenoten, Memory Plus with Neurotropin-mexibel, Elfunat, Nucleo CMF Forte and Cytoflavin with Cebrilysin.

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